Our research seeks to understand large-scale circuits in the brain and engineer novel brain-based therapies.
The brain is a network. We want to know how the activity of neurons in one part of the network depends on and relates to the rest of the network.
Even an act as simple as looking and reaching to pick up a cup recruits neurons throughout the brain. What are these neurons saying to each other? Read More…
Neurons in different regions of the brain have access to different kinds of information. When we are faced with a choice, the different regions exchange information with each other. Who decides? Read More…
Kevin Brown, David Hawellek, Breonna Ferrentino, Shaoyu Qiao, Yan Wong
Language is a uniquely human property of the brain but speaking depends on constructing a sensory-motor interface, something all brains must do. How are our brains unique? Read More…
Understanding how neurons work together in large-scale circuits depends on developing new technologies to precisely map, monitor and control neuronal activity across the circuit. Read More…
Advanced technologies are needed to treat neurological disorders. We are studying how to sample neural signals in the brain to develop reliable and effective neural interfaces for clinical translation. Read More…
Our next steps are to study neural population dynamics during gaze-anchoring, image and manipulate the different cell-types in this circuit, and investigate how multiregional beta coherence is orchestrated by the prefrontal cortices.
These results highlight how spike timing at the 20ms time-scale is critical to explaining behavioral flexibility and variations in movement performance due to cognitive mechanisms that recruit inhibitory multiregional communication.
We tested the channel-modulation hypothesis by predicting the firing of area LIP neurons trial by trial using PRR neuron firing which determines the input gain, and the beta coherence which determines the modulation state. Beta coherence may modulate feedforward inhibition. pic.twitter.com/AvmFnGrNfg