Coordination

Even an act as simple as looking and reaching to pick up a cup recruits neurons throughout the brain. What are these neurons saying to each other? Read More…

Decision-making

Neurons in different regions of the brain have access to different kinds of information. When we are faced with a choice, the different regions exchange information with each other. Who decides? Read More…

Speech

Language is a uniquely human property of the brain but speaking depends on constructing a sensory-motor interface, something all brains must do. How are our brains unique? Read More…

Brain mapping

Understanding how neurons work together in large-scale circuits depends on developing new technologies to precisely map, monitor and control neuronal activity across the circuit. Read More…

Brain-machine Interfaces

Advanced technologies are needed to treat neurological disorders. We are studying how to sample neural signals in the brain to develop reliable and effective neural interfaces for clinical translation. Read More…

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6/6 Our results inform next-generation brain therapies for disordered brain networks. An excitability-based neuromodulation brain-machine interface can decode modulator network state and deliver targeted neuromodulation that controls multiregional communication .

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5/6 Decoding network excitability from neural activity at modulator sites predicted sender-receiver communication while sbTetMS neuromodulation temporarily disrupted communication.

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4/6 The causal network analysis revealed a mechanism of network excitability that regulates when a sender stimulation site communicates with receiver sites.

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